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GREM1抗原(重組蛋白)

品牌:紀(jì)寧生物

貨號:JN7577

規(guī)格: 1mg 100ug

聯(lián)系方式:021-54721350

立即詢價(jià) 說明書下載

產(chǎn)品詳情

中文名稱:GREM1抗原(重組蛋白)


英文名稱: GREM1 Antigen (Recombinant Protein)


儲      存: 冷凍(-20℃)


相關(guān)類別: 抗原


概述

 

Fusion protein corresponding to a region derived from 25-184 amino acids of human GREM1

 

技術(shù)規(guī)格

 

Full name:

gremlin 1, DAN family BMP antagonist

Synonyms:

DRM; HMPS; MPSH; PIG2; CRAC1; CRCS4; DAND2; HMPS1; IHG-2; DUP15q; C15DUPq; GREMLIN; CKTSF1B1

Swissprot:

O60565

Gene Accession:

BC069525

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

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