手機(jī)掃碼訪問本站
微信咨詢
中文名稱:GRK4抗原(重組蛋白)
英文名稱: GRK4 Antigen (Recombinant Protein)
儲 存: 冷凍(-20℃)
相關(guān)類別: 抗原
概述
Fusion protein corresponding to a region derived from 36-145 amino acids of human GRK4 |
技術(shù)規(guī)格
Full name: |
G protein-coupled receptor kinase 4 |
Synonyms: |
IT11; GPRK4; GRK4a; GPRK2L |
Swissprot: |
P32298 |
Gene Accession: |
BC117320 |
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
Expression system: |
Escherichia coli |
Tags: |
His tag C-Terminus, GST tag N-Terminus |
Background: |
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2. |