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中文名稱： GCLC 抗原（重組蛋白）
英文名稱： GCLC Antigen (Recombinant Protein)
別 名： glutamate-cysteine ligase, catalytic subunit; GCL; GCS; GLCL; GLCLC
相關(guān)類別： 抗原
儲(chǔ) 存 ：冷凍（-20℃）
概述
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Fusion protein corresponding to N terminal 252 amino acids of human GCLC |
技術(shù)規(guī)格
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Full name: |
glutamate-cysteine ligase, catalytic subunit |
|
Synonyms: |
GCL; GCS; GLCL; GLCLC |
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Swissprot: |
P48506 |
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Gene Accession: |
BC022487 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction. |
