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中文名稱: 兔抗PSEN1多克隆抗體


英文名稱: Anti-PSEN1 rabbit polyclonal antibody


別      名: presenilin 1 AD3; FAD; PS1; PS-1; S182


相關(guān)類別: 一抗


抗     原: PSEN1


儲(chǔ)     存: 冷凍(-20℃)


宿     主: Rabbit


反應(yīng)種屬: Human, Mouse


標(biāo)  記  物: Unconjugate


克隆類型: rabbit polyclonal


技術(shù)規(guī)格


Background:

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.

Applications:

ELISA, WB, IHC

Name of antibody:

PSEN1

Immunogen:

Synthetic peptide of human PSEN1

Full name:

presenilin 1

Synonyms:

AD3; FAD; PS1; PS-1; S182

SwissProt:

P49768

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human liver cancer;

IHC Recommend dilution:

20-100

WB Predicted band size:

53 kDa

WB Positive control:

Human kidney tissue,RAW264.7 cell,Mouse kidney tissue,Mouse liver tissue lysates

WB Recommended dilution:

200-1000







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