Background:

This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms.

Applications:

ELISA, WB

Name of antibody:

TREM2

Immunogen:

Synthetic peptide of human TREM2

Full name:

triggering receptor expressed on myeloid cells 2

Synonyms:

PLOSL2; TREM-2; Trem2a; Trem2b; Trem2c

SwissProt:

Q9NZC2

ELISA Recommended dilution:

5000-10000

WB Predicted band size:

25 kDa

WB Positive control:

Mouse heart tissue, Human cerebella tissue, Human cerebrum tissue, Mouse liver tissue lysates

WB Recommended dilution:

1000-5000