Background:

This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which lies inside the cytoplasmic membrane and is essential for cytokinesis. This human protein functions in gliomagenesis and in the suppression of glioma cell growth, and it is required for the association of centromere-associated protein E with the kinetochore. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified on chromosomes 5, 7, 9, 10, 11, 14, 17 and 19.

Applications:

WB

Name of antibody:

SEPT7

Immunogen:

Synthesized peptide derived from internal of human SEPT7.

Full name:

septin 7

Synonyms:

CDC3; CDC10; SEPT7A; NBLA02942

SwissProt:

Q16181

WB Predicted band size:

51 kDa

WB Positive control:

MCF-7 cell lysate

WB Recommended dilution:

500-3000