Background:

This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease.

Applications:

WB, IHC

Name of antibody:

NFKBIA(Ab-32/36)

Immunogen:

Synthesized non-phosphopeptide derived from human IκB-α around the phosphorylation site of Serine 32/36.

Full name:

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha

Synonyms：

IKBA; MAD-3; NFKBI

SwissProt:

P25963

IHC positive control:

Human breast carcinoma tissue

IHC Recommend dilution:

50-100

WB Predicted band size:

36 kDa

WB Positive control:

MCF7 cells treated with TNF-α lysate

WB Recommended dilution:

500-3000