Background:

Retinoblastoma-like protein 2 is a protein that in humans is encoded by the RBL2 gene. Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation.

Applications:

ELISA, WB, IHC

Name of antibody:

RBL2

Immunogen:

Synthetic peptide of human RBL2

Full name:

retinoblastoma-like 2

Synonyms:

Rb2; P130

SwissProt:

Q08999

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human lung cancer and human brain

IHC Recommend dilution:

30-150

WB Predicted band size:

128 kDa

WB Positive control:

Lncap cell

WB Recommended dilution:

200-1000