Background:

The protein encoded by this gene contains a proline-rich region, a pleckstrin homology (PH) domain, and a region in the carboxy terminal half with similarity to the Src Homology 2 (SH2) domain. This protein is a substrate of tyrosine-protein kinase Tec, and its interaction with tyrosine-protein kinase Tec is phosphorylation-dependent. This protein is thought to participate in a positive feedback loop by upregulating the activity of tyrosine-protein kinase Tec. Variants of this gene have been associated with autosomal-dominant hypercholesterolemia (ADH), which is characterized by elevated low-density lipoprotein cholesterol levels and in increased risk of coronary vascular disease. Alternative splicing results in multiple transcript variants.

Applications:

ELISA, IHC

Name of antibody:

STAP1

Immunogen:

Fusion protein of human STAP1

Full name:

signal transducing adaptor family member 1

Synonyms:

BRDG1; STAP-1

SwissProt:

Q9ULZ2

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human liver cancer and human esophagus cancer

IHC Recommend dilution:

25-100