Background:

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones.

Applications:

WB, IHC

Name of antibody:

STAT5B(Ab-731)

Immunogen:

Synthesized non-phosphopeptide derived from human STAT5B around the phosphorylation site of serine 731(A-P-S-P-A).

Full name:

signal transducer and activator of transcription 5B

Synonyms：

STAT5

SwissProt:

P51692

IHC positive control:

Human colon carcinoma tissue

IHC Recommend dilution:

50-100

WB Predicted band size:

90 kDa

WB Positive control:

RAW264.7 cells treated with EGF (200ng/ml 30min) lysate

WB Recommended dilution:

500-3000