Background:

Arg and c-Abl represent the mammalian members of the Abelson family of non-receptor protein-tyrosine kinases. They interact with the Arg/Abl binding proteins via the SH3 domains present in the carboxy end of the latter group of proteins. This gene encodes the sorbin and SH3 domain containing 2 protein. It has three C-terminal SH3 domains and an N-terminal sorbin homology (SoHo) domain that interacts with lipid raft proteins. The subcellular localization of this protein in epithelial and cardiac muscle cells suggests that it functions as an adapter protein to assemble signaling complexes in stress fibers, and that it is a potential link between Abl family kinases and the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms.

Applications:

ELISA, WB, IHC

Name of antibody:

SORBS2

Immunogen:

Fusion protein of human SORBS2

Full name:

sorbin and SH3 domain containing 2

Synonyms:

ARGBP2; PRO0618

SwissProt:

O94875

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human liver cancer

IHC Recommend dilution:

150-300

WB Predicted band size:

124 kDa

WB Positive control:

LO2 and 231 cell lysates

WB Recommended dilution:

1000-5000