Background:

This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Applications:

ELISA, WB, IHC

Name of antibody:

SPHK2

Immunogen:

Fusion protein of human SPHK2

Full name:

sphingosine kinase 2

Synonyms：

SK 2; SK-2; SPK 2; SPK-2

SwissProt:

Q9NRA0

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human thyroid cancer

IHC Recommend dilution:

25-100

WB Predicted band size:

69 kDa

WB Positive control:

Mouse brain and liver tissue

WB Recommended dilution:

200-1000