Background:

The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway.

Applications:

ELISA, IHC

Name of antibody:

TRADD

Immunogen:

Fusion protein of human TRADD

Full name:

TNFRSF1A associated via death domain

Synonyms:

Hs.89862

SwissProt:

Q15628

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human colorectal cancer and Human thyroid cancer

IHC Recommend dilution:

100-300