Background:

Speedy A, also known as SPDYA, SPDY1, Ringo3 or SPY1, is a 313 amino acid protein that localizes to the nucleus and belongs to the speedy/ringo family. Expressed at high levels in testis and at lower levels in brain, kidney, heart, bone marrow, colon, lung, liver spleen and placenta, Speedy A functions to regulate the G1/S phase transition of the cell cycle, specifically by binding to and activating Cdc2 p34, Cdk2 and p27. Additionally, Speedy A mediates cell survival during DNA damage, suggesting that Speedy A plays a role in proper cell cycle progression throughout the life of the cell. Multiple isoforms of Speedy A exist due to alternative splicing events. The gene encoding Speedy A maps to human chromosome 2, which encodes over 1,400 genes and comprises nearly 8% of the human genome.

Applications:

WB

Name of antibody:

SPDYA

Immunogen:

Fusion protein of human SPDYA

Full name:

speedy homolog A (Xenopus laevis)

Synonyms：

MGC110856; MGC57218; Ringo3; SPDY1; SPY1

SwissProt:

Q5MJ70

WB Predicted band size:

36 kDa

WB Positive control:

NT2D1, PC3 and U-67 cells

WB Recommended dilution:

500-2000