Background:

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associates with the long isoform of the leptin receptor, the transforming growth factor-beta family of receptor serine-threonine kinases, and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor. This protein may form oligomeric complexes with family member proteins through interactions of both the PX domain and the coiled coil regions of the molecules. Translocation of this protein from the cytoplasm to the nucleus occurs after binding to proviral integration site 1 protein. This gene results in two transcripts encoding two distinct isoforms.

Applications:

ELISA, IHC

Name of antibody:

SNX6

Immunogen:

Synthetic peptide of human SNX6

Full name:

sorting nexin 6

Synonyms:

TFAF2; MSTP010

SwissProt:

Q9UNH7

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human esophagus cancer; Human liver cancer

IHC Recommend dilution:

50-300