Background:

E3 ubiquitin-protein ligase SMURF2 is an enzyme that in humans is encoded by the SMURF2 gene. E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3.

Applications:

ELISA, IHC

Name of antibody:

SMURF2

Immunogen:

Synthetic peptide of human SMURF2

Full name:

SMAD specific E3 ubiquitin protein ligase 2

SwissProt:

Q9HAU4

IHC positive control:

Human gastric cancer and human liver cancer

IHC Recommend dilution:

25-100