Background:

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene.

Applications:

ELISA, IHC

Name of antibody:

SIRT3

Immunogen:

Fusion protein of human SIRT3

Full name:

Sirtuin 3

Synonyms：

SIR2L3

SwissProt:

Q9NTG7

ELISA Recommended dilution:

1000-2000

IHC positive control:

Human brain and human liver cancer

IHC Recommend dilution:

15-50