Background:

This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene.

Applications:

ELISA, WB, IHC

Name of antibody:

MVP

Immunogen:

Fusion protein of human MVP

Full name:

major vault protein

Synonyms：

LRP, VAULT1

SwissProt:

Q14764

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human lung cancer and Human esophagus cancer

IHC Recommend dilution:

25-100

WB Predicted band size:

99 kDa

WB Positive control:

231 cells and mouse kidney tissue

WB Recommended dilution:

500-2000