Background:

PLEKHG6 functions as a guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. It activates RHOG but not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving MyoGEF, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis.

Applications:

ELISA, WB, IHC

Name of antibody:

PLEKHG6

Immunogen:

Fusion protein of human PLEKHG6

Full name:

pleckstrin homology domain containing, family G (with RhoGef domain) member 6

Synonyms：

MyoGEF

SwissProt:

Q3KR16

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human lung cancer and human cervical cancer

IHC Recommend dilution:

100-300

WB Predicted band size:

89 kDa

WB Positive control:

231 cells

WB Recommended dilution:

500-2000