Background:

This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3' UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.

Applications:

WB

Name of antibody:

PHB(Phospho-Tyr253)

Immunogen:

Peptide sequence around phosphorylation site of tyrosine 253 (L-S-R(p)-S-R) derived from Human PHB.

Full name:

prohibitin

Synonyms：

PHB1; HEL-215; HEL-S-54e

SwissProt:

P35232

WB Predicted band size:

30 kDa

WB Positive control:

MCF, PC12, 293 and NIH/3T3 cells lysates

WB Recommended dilution:

500-1000