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英文名稱： ZKSCAN3 Antigen (Recombinant Protein)
別 名： zinc finger with KRAB and SCAN domains 3; ZF47; Zfp47; ZFP306; ZNF306; ZNF309; zfp-47; ZSCAN13; ZSCAN35; dJ874C20.1;
dJ874C20.1.
相關類別： 抗原
儲 存： 冷凍（-20℃）
概述
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Fusion protein corresponding to a region derived from 339-538 amino acids of human ZKSCAN3 |
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Full name: |
zinc finger with KRAB and SCAN domains 3 |
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Synonyms: |
ZF47; Zfp47; ZFP306; ZNF306; ZNF309; zfp-47; ZSCAN13; ZSCAN35; dJ874C20.1; dJ874C20.1. |
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Swissprot: |
Q9BRR0 |
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Gene Accession: |
BC006118 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
Transcriptional factor that binds to the consensus sequence 5'-[GT][AG][AGT]GGGG-3' and acts as a repressor of autophagy. Specifically represses expression of genes involved in autophagy and lysosome biogenesis/function such as MAP1LC3B, ULK1 or WIPI2. Associates with chromatin at the ITGB4 and VEGF promoters. Also acts as a transcription activator and promotes cancer cell progression and/or migation in various tumors and myelomas. |
