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兔抗WWTR1多克隆抗體

品牌:紀(jì)寧生物

貨號:JN15553

規(guī)格: 100ul 200ul 25ul

聯(lián)系方式:021-54721350

立即詢價 說明書下載

產(chǎn)品詳情

中文名稱: 兔抗WWTR1多克隆抗體

英文名稱: Anti-WWTR1 rabbit polyclonal antibody

別       名: WW domain containing transcription regulator 1; TAZ

抗       原: WWTR1 

相關(guān)類別: 一抗

儲       存: 冷凍(-20℃)

宿       主: Rabbit

反應(yīng)種屬: Human, Mouse

標(biāo) 記  物: Unconjugate

克隆類型: rabbit polyclonal

技術(shù)規(guī)格

Background:

The transcriptional co-activator with PDZ-binding motif (TAZ) is a 14-3-3-binding molecule. The highly conserved and ubiquitously expressed 14-3-3 proteins regulate differentiation, cell cycle progression and apoptosis by binding intracellular phosphoproteins involved in signal transduction. TAZ may link events at the plasma membrane and cytosketeton to nuclear transcription in a manner that can be regulated by 14-3-3. TAZ shares homology with the WW domain of Yes-associated protein (YAP) and functions as a transcriptional co-activator by binding to the PPXY motif present on transcription factors. TAZ recognizes immunoreactive protein bands in lysates from MDCK, NIH-3T3 and 293T cells. In addition, COS7, Hep G2, CHO and HeLa cells express endogenous TAZ. 14-3-3 binding requires TAZ phosphorylation on a single Serine 89 residue, resulting in the inhibition of TAZ transcriptional co-activation through 14-3-3-mediated nuclear export.

Applications:

ELISA, WB

Name of antibody:

WWTR1

Immunogen:

Synthetic peptide of human WWTR1

Full name:

WW domain containing transcription regulator 1

Synonyms:

TAZ

SwissProt:

Q9GZV5

ELISA Recommended dilution:

5000-10000

WB Predicted band size:

44 kDa

WB Positive control:

HEPG2, Jurkat, A431 and NIH/3T3 cell lysates

WB Recommended dilution:

200-1000


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