Background:

This gene encodes one of the three prealbumins, which include alpha-1-antitrypsin, transthyretin and orosomucoid. The encoded protein, transthyretin, is a homo-tetrameric carrier protein, which transports thyroid hormones in the plasma and cerebrospinal fluid. It is also involved in the transport of retinol (vitamin A) in the plasma by associating with retinol-binding protein. The protein may also be involved in other intracellular processes including proteolysis, nerve regeneration, autophagy and glucose homeostasis. Mutations in this gene are associated with amyloid deposition, predominantly affecting peripheral nerves or the heart, while a small percentage of the gene mutations are non-amyloidogenic. The mutations are implicated in the etiology of several diseases, including amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis and carpal tunnel syndrome.

Applications:

ELISA, WB, IHC

Name of antibody:

TTR

Immunogen:

Fusion protein of human TTR

Full name:

transthyretin

Synonyms:

CTS; ATTR; CTS1; PALB; TBPA; HEL111; HsT2651

SwissProt:

P02766

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human liver cancer and Human esophagus cancer

IHC Recommend dilution:

50-200

WB Predicted band size:

16 kDa

WB Positive control:

Mouse serum

WB Recommended dilution:

500-2000