Full name:

fibronectin type III domain containing 3B

Synonyms:

FAD104; PRO4979; YVTM2421

Swissprot:

Q53EP0

Gene Accession:

BC012204

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

Adipogenesis, the process of transforming pre-adipocytes into mature fat cells, is of particular interest due to the role adipocytes play in obesity and type II diabetes. Adipocytes have been shown to affect a variety of functions, including hemostasis, angiogenesis and energy balance, by secreting hormones and bioactive peptides. The FNDC3B protein, also designated FAD104 (factor for adipocyte differentiation 104) or HCV NS5A-binding protein 37, is expressed during early adipogenesis. Belonging to the FNDC3 family of proteins, FNDC3B is a 1,204 amino acid protein that contains nine fibronectin type-III domains. FNDC3B-deficient mice die within one day of birth, suggesting that FNDC3B is crucial for postpartum survival. Mouse embryonic fibroblasts (MEFs) with loss of FNDC3B function displayed a reduction in stress fiber formation, indicating a role for FNDC3B in cell proliferation, adhesion, spreading and migration.