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英文名稱： MCM6 Antigen (Recombinant Protein)
別 名： Mis5; P105MCM; MCG40308
儲 存： 冷凍（-20℃）
相關(guān)類別： 抗原
概 述
Fusion protein corresponding to C terminal 300 amino acids of human MCM6
技術(shù)規(guī)格
Full name:
minichromosome maintenance complex component 6
Synonyms:
Mis5; P105MCM; MCG40308
Swissprot:
Q14566
Gene Accession:
BC032374
Purity:
>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:
Escherichia coli
Tags:
His tag C-Terminus, GST tag N-Terminus
Background:
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication.
