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英文名稱 : DPYD Antigen (Recombinant Protein)
別 名 : DHP; DPD; DHPDHASE
儲(chǔ) 存 : 冷凍(-20℃)
相關(guān)類別: 抗原
概述
Full length fusion protein |
Full name: |
dihydropyrimidine dehydrogenase |
Synonyms: |
DHP; DPD; DHPDHASE |
Swissprot: |
Q12882 |
Gene Accession: |
BC008379 |
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
Expression system: |
Escherichia coli |
Tags: |
His tag C-Terminus, GST tag N-Terminus |
Background: |
The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene. |