Background:

The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene.

Applications:

ELISA, IHC

Name of antibody:

FUT3

Immunogen:

Synthetic peptide of human FUT3

Full name:

fucosyltransferase 3 (Lewis blood group)

Synonyms:

LE; Les; FT3B; CD174; FucT-III

SwissProt:

P21217

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human cervical cancer and Human ovarian cancer

IHC Recommend dilution:

40-200