Background:

FUNDC2 (FUN14 domain-containing protein 2), also known as HCC-3 (cervical cancer proto-oncogene 3 protein), HCBP6 (hepatitis C virus core-binding protein 6) or DC44, is a 189 amino acid protein belonging to the FUN14 family. The gene encoding FUNDC2 maps to human chromosome Xq28. The X and Y chromosomes are the human sex chromosomes. Chromosome X consists of about 153 million base pairs and nearly 1,000 genes. The combination of an X and Y chromosome lead to normal male development while two copies of X lead to normal female development. More than one copy of the X chromosome with a Y chromosome causes Klinefelter's syndrome. A single copy of X alone leads to Turner's syndrome. More than 2 copies of the X chromosome, in the absence of a Y chromosome, is known as Triple X syndrome. Color blindness, hemophilia, and Duchenne muscular dystrophy are well known X chromosome-linked conditions which affect males more frequently as males carry a single X chromosome.

Applications:

ELISA, IHC

Name of antibody:

FUNDC2

Immunogen:

Fusion protein of human FUNDC2

Full name:

FUN14 domain containing 2

Synonyms:

DC44; HCC3; HCBP6; PD03104

SwissProt:

Q9BWH2

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human tonsil and Human thyroid cancer

IHC Recommend dilution:

50-300